Homemade Southern Chicken Spaghetti Casserole Recipe

Name: Homemade Southern Chicken Spaghetti Casserole Recipe
Prep time: 15 min
Cook time: 30 min
Total time: 45 min
Yield: 6.0
Ingredients: 2 cups cooked chicken, shredded; 8 ounces spaghetti, cooked; 1 can cream of mushroom soup; 1 cup diced tomatoes with green chilies; 1 cup shredded cheddar cheese; 1/2 cup milk; 1/2 cup chopped bell pepper; 1/2 cup chopped onion; Salt and pepper to taste; 1 teaspoon garlic powder

Highlighted under: Comfort Food

Experience comfort food at its finest with this Southern Chicken Spaghetti Casserole recipe, bursting with spicy flavors and creamy goodness. Perfect for a family dinner or potluck gathering, this dish combines tender chicken, al dente pasta, and a zesty sauce that's simply irresistible. Easy to prepare and even easier to devour, this casserole will become a staple in your meal rotation.

Created by

Clara Jennings

Last updated on 2025-12-12T02:06:38.831Z

This homemade Southern Chicken Spaghetti Casserole is a delightful blend of flavors that embodies the essence of comfort food. Made with love, it's a recipe that has been passed down through generations, making it ideal for family gatherings or cozy weeknight dinners.

A Southern Classic with a Twist

Chicken spaghetti is a beloved tradition in many Southern households, often passed down through generations. This casserole takes that classic dish and infuses it with a modern flair by incorporating zesty diced tomatoes and a rich cream of mushroom sauce. The result? A comforting meal that's not only hearty but also packed with flavors that dance on your palate.

What sets this chicken spaghetti casserole apart is its ease of preparation. In just a few simple steps, you can create a dish that feels like a labor of love. Ideal for busy weeknights or unexpected guests, this recipe ensures that a scrumptious meal is always within reach, keeping everyone at the table satisfied.

Versatility at Its Best

One of the many reasons you'll appreciate this casserole is its versatility. You can easily make it your own by swapping in different vegetables or proteins. For example, if you have leftover turkey, use that instead of chicken. Vegetarians can opt for a mix of mushrooms and spinach to create a wholesome alternative, making it a dish everyone can enjoy regardless of dietary preferences.

Furthermore, this casserole is perfect for meal prepping. You can assemble it ahead of time and refrigerate it until you're ready to bake. Even better, leftovers reheat beautifully, ensuring that your family can enjoy this delicious dish multiple times without feeling like they're eating the same meal again.

Perfect for Any Occasion

Whether it's a casual family dinner, a Sunday gathering, or a potluck with friends, this Southern Chicken Spaghetti Casserole is a surefire hit. Its creamy texture and savory flavors will win over even the pickiest eaters. Pair it with a simple green salad or some garlic bread, and you’ve got a complete meal that’s sure to impress.

The appeal of this casserole extends beyond taste. It also evokes a sense of nostalgia, often reminding people of family gatherings and cherished memories. It's not just a meal; it's a bonding experience, bringing family and friends together around the table.

Ingredients

Gather your ingredients before starting.

Ingredients

2 cups cooked chicken, shredded
8 ounces spaghetti, cooked
1 can cream of mushroom soup
1 cup diced tomatoes with green chilies
1 cup shredded cheddar cheese
1/2 cup milk
1/2 cup chopped bell pepper
1/2 cup chopped onion
Salt and pepper to taste
1 teaspoon garlic powder

Make sure to have everything prepped and ready.

Instructions

Follow these steps to create your casserole.

Preheat the Oven

Preheat your oven to 350°F (175°C).

Combine Ingredients

In a large mixing bowl, combine the cooked chicken, spaghetti, cream of mushroom soup, diced tomatoes, cheddar cheese, milk, bell pepper, onion, salt, pepper, and garlic powder. Mix well.

Transfer to Casserole Dish

Pour the mixture into a greased 9x13-inch casserole dish, spreading it evenly.

Bake

Bake in the preheated oven for 25–30 minutes, or until the top is golden and bubbly.

Serve

Remove from the oven and let it cool for a few minutes before serving.

Enjoy your delicious casserole!

Additional Tips for Success

To enhance the flavor of your chicken spaghetti casserole, consider marinating your chicken in a blend of spices or using rotisserie chicken for added depth. You can also add a splash of hot sauce for an extra kick if you enjoy a bit of heat in your meals.

Be sure to pay attention to the cheese you choose. A combination of cheddar and Monterey Jack adds a great depth of flavor and creaminess. You can also try a sprinkle of Parmesan on top for a golden, bubbly crust during baking.

Storage and Reheating Instructions

Once you've made your delicious casserole, any leftovers can be stored in an airtight container in the refrigerator for up to three days. This makes it a perfect option for meal prep or late-night snacks. Just make sure to cool it completely before sealing it up for storage.

When you're ready to enjoy the leftovers, reheat in the oven at 350°F (175°C) for about 15-20 minutes or until heated through. You can also microwave individual portions if you're in a hurry. Just pop it in until warm, stirring occasionally to ensure even heating.

Questions About Recipes

→ Can I make this casserole ahead of time?

Yes, you can prepare the casserole a day ahead, cover it, and refrigerate it until you're ready to bake.

→ Can I freeze leftovers?

Absolutely! Just ensure it's stored in an airtight container and it should last for up to 3 months in the freezer.